A latent measure explains substantial variance in white matter microstructure across the newborn human brain.

ABSTRACT: A latent measure of white matter microstructure (g _WM) provides a neural basis for information processing speed and intelligence in adults, but the temporal emergence of g _WM during human development is unknown. We provide evidence that substantial variance in white matter microstructure is shared across a range of major tracts in the newborn brain. Based on diffusion MRI scans from 145 neonates [gestational age (GA) at birth range 23⁺²-41⁺⁵ weeks], the microstructural properties of eight major white matter tracts were calculated using probabilistic neighborhood tractography. Principal component analyses (PCAs) were carried out on the correlations between the eight tracts, separately for four tract-averaged water diffusion parameters: fractional

SUBMITTER: Telford EJ 

PROVIDER: S-EPMC5686254 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature