Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling.

ABSTRACT: Cohabitation of microbial communities with the host enables the formation of a symbiotic relationship that maintains homeostasis in the gut and beyond. One prevailing model suggests that this relationship relies on the capacity of host cells and tissues to remain tolerant to the strong immune stimulation generated by the microbiota such as the activation of Toll-like receptor 4 (TLR4) pathways by lipopolysaccharide (LPS). Indeed, gut microbial LPS is thought to be one of the most potent activators of innate immune signaling and an important mediator of the microbiome's influence on host physiology. In this study, we performed computational and experimental analyses of healthy human fecal samples to examine the TLR4 signaling capacity of the gut microbiota. These analyses revealed that an i

SUBMITTER: d'Hennezel E 

PROVIDER: S-EPMC5686520 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature