Acute Homeostatic Changes Following Vitamin D₂ Supplementation.

ABSTRACT:

Context

Changes in vitamin D binding protein (DBP) concentrations and catabolism of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D (24,25D) after vitamin D2 supplementation may alter concentrations and bioavailability of circulating 25-hydroxyvitamin D (25D).

Objective

Examine acute changes in vitamin D metabolism and bioavailability after vitamin D2 supplementation.

Methods

Study design was secondary analysis of a single-arm interventional study. Thirty consenting volunteers were treated with five 50,000 IU oral doses of ergocalciferol over 2 weeks. Main outcome measures included concentrations of DBP, vitamin D metabolites, and bioavailable 25-hydroxyvitamin D (25D) in pre- and posttreatment serum samples.

Results

After supplementation, 25D₂ (mean

SUBMITTER: Berg AH 

PROVIDER: S-EPMC5686571 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature