Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women.

ABSTRACT:

Context

Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages. In humans, bariatric surgery-induced weight loss leads to a decrease in CLSs, but the effects of rapid diet-induced weight loss on CLSs and metabolism are unclear.

Objective

To determine the effects of rapid very-low-calorie diet-induced weight loss on CLS density, systemic biomarkers of inflammation, and metabolism in obese postmenopausal women.

Design

Prospective cohort study.

Setting

Rockefeller University Hospital, New York, NY.

Participants

Ten obese, postmenopausal women with a mean age of 60.6 years (standard deviation, ±3.6 years).

Main outc

SUBMITTER: Aleman JO 

PROVIDER: S-EPMC5686624 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature