Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals.

ABSTRACT:

Context

Aldosterone synthase (CYP11B2) immunohistochemistry and next-generation sequencing (NGS) have revealed the frequent presence of aldosterone-producing cell clusters (APCCs) harboring somatic mutations in aldosterone-regulating genes in adrenals from Americans without defined hypertension status.

Objective

Determine the frequency and somatic mutation status of APCCs in a Japanese nonhypertensive cohort.

Design setting patients and interventions

Adrenals from 837 consecutive autopsies at a Japanese institution, Tohoku University Hospital, were screened to select 107 unilateral adrenal glands from nonhypertensive patients. APCC score (APCC number/adrenal cortex area per case) was assessed by CYP11B2 immunohistochemistry. DNA from all APCCs and adjacent adrenal cor

SUBMITTER: Omata K 

PROVIDER: S-EPMC5686701 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature