Mutational Analysis of ZFY in Sporadic Parathyroid Adenomas.

ABSTRACT:

Context

The molecular pathogenesis of sporadic parathyroid adenomas is incompletely understood, with alterations in cyclin D1/PRAD1 and MEN1 most firmly established as genetic drivers. The gene encoding the X-linked zinc finger protein (ZFX) has recently been implicated in the pathogenesis of a subset of parathyroid adenomas after recurrent, hotspot-focused somatic mutations were identified. ZFX escapes X inactivation and is transcribed from both alleles in women, and a highly homologous gene encoding the Y-linked zinc finger protein (ZFY) provides dosage compensation in males.

Objective

We sought to investigate the role of ZFY mutation in sporadic parathyroid adenoma.

Intervention

Polymerase chain reaction and Sanger sequenci

SUBMITTER: Romano R 

PROVIDER: S-EPMC5686765 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature