Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD.

Methods

We performed in vivo two-photon calcium imaging to examine the activities of somas, dendrites and dendritic spines of layer 2/3 pyramidal neurons in the primary motor cortex in the APPswe/PS1dE9 mouse model of AD and age-matched wild type control mice. We also performed calcium imaging to determine the effect of Aβ oligomers on dendritic calcium activity. In addition, structural and functional two-photon imaging were used to examine the link between abnormal d

SUBMITTER: Bai Y 

PROVIDER: S-EPMC5686812 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature