Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay.

ABSTRACT: Migrating cells often exhibit signal relay, a process in which cells migrating in response to a chemotactic gradient release a secondary chemoattractant to enhance directional migration. In neutrophils, signal relay toward the primary chemoattractant N--formylmethionyl-leucyl-phenylalanine (fMLP) is mediated by leukotriene B₄ (LTB₄). Recent evidence suggests that the release of LTB₄ from cells occurs through packaging in exosomes. Here we present a mathematical model of neutrophil signal relay that focuses on LTB₄ and its exosome-mediated secretion. We describe neutrophil chemotaxis in response to a combination of a defined gradient of fMLP and an evolving gradient of LTB₄, generated by cells in response to fMLP. Our model enables us t

SUBMITTER: Szatmary AC 

PROVIDER: S-EPMC5687044 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature