Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children.

ABSTRACT:

Objective

To perform whole exome sequencing in 928 Hispanic children and identify variants and genes associated with childhood obesity.

Methods

Single-nucleotide variants (SNVs) were identified from Illumina whole exome sequencing data using integrated read mapping, variant calling, and an annotation pipeline (Mercury). Association analyses of 74 obesity-related traits and exonic variants were performed using SeqMeta software. Rare autosomal variants were analyzed using gene-based association analyses, and common autosomal variants were analyzed at the SNV level.

Results

(1) Rare exonic variants in 10 genes and 16 common SNVs in 11 genes that were associated with obesity traits in a cohort of Hispanic children were identified, (2) novel rare variants in peroxisome bio

SUBMITTER: Sabo A 

PROVIDER: S-EPMC5687071 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature