Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC5687282 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20171012 2
Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. However, the mechanism is unclear. Here, we report that mitophagy, the selective removal of mitochondria by autophagy, positively regulates hepatic cancer stem cells (CSCs) by suppressing the tumor suppressor p53. When mitophagy is enhanced, p53 co-localizes with mitochondria and is removed by a mitophagy-dependent manner. However, when mitophagy is inhibited, p53 is phosphorylated at serine-392 ...[more]