Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development.

ABSTRACT: Liver kinase B 1 (LKB1 or STK11) and PTEN (phosphatase and tensin homologue deleted on chromosome 10) are two tumor suppressors that regulate the mTOR signaling pathway. Deletion studies show that loss of either Lkb1 (Lkb^+/- ) or Pten (Pten^loxP/loxP; Alb-Cre⁺ ) leads to liver injury and development of hepatocarcinoma. In this study, we investigated the crosstalk of LKB1 and PTEN loss during tumorigenesis and liver development. We show here that haplo-insufficiency of Lkb1 in the liver leads to advanced tumor development in the Pten null mice (Pten^loxP/loxP; Lkb^loxP/+; Alb-Cre⁺ ). Our analysis shows that LKB1 and PTEN interacted with each other in their regulation of fatty acid

SUBMITTER: Jia C 

PROVIDER: S-EPMC5687583 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature