Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia.

ABSTRACT:

Purpose

The incidence of benign prostatic hyperplasia increases among obese individuals, but few studies have fully explained the underlying mechanisms. Adiponectin has drawn much attention in recent years due to its protective role in obesity-related diseases. Here we aimed to investigate the possible molecular mechanisms and clinical significance of adiponectin in relation to benign prostatic hyperplasia.

Methods

We analyzed data from 98 Chinese men, including 48 BPH cases and 50 controls in a case-control study. Then, we utilized a tissue microarray analysis to examine expression of AdipoR1 and p-p90RSK in normal and hyperplastic prostate tissues. These studies were followed by various in vitro approaches to examine the anti-proliferation effect and signaling pathw

SUBMITTER: Fu S 

PROVIDER: S-EPMC5687625 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature