A complex microsatellite at chromosome 7q33 as a new prognostic marker of colorectal cancer.

ABSTRACT: Disease-specific markers are critical for early diagnosis, targeted therapy and prognostic prediction of diseases. Current study reports a complex microsatellite as a new prognostic marker of sporadic colorectal cancer. This microsatellite located at Chromosome 7q33 is composed of three tetranucleotide tandem repeats, (TTCC)₂(TCCC)₅(TCCT)₇, flanked by a CT-rich sequence. We analyzed polymorphisms of this microsatellite in 158 sporadic colorectal cancer, 143 matched normal adjacent tissues (NAT) and 150 health donors. Our results showed that this complex microsatellite was instable with polymorphic frequency of 77.2% in colorectal cancer, 52.4% in NAT and 54.7% in health donors (p<0.01) when compared to reference sequence. In the three tandem repeats, (TCCT)

SUBMITTER: Ye X 

PROVIDER: S-EPMC5687643 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature