Meta-analysis of the clinical value of abnormally expressed long non-coding RNAs for pancreatic cancer.

ABSTRACT: Pancreatic cancer (PC) is one of the most lethal malignant neoplasms of the digestive system. Long non-coding RNAs (lncRNAs) are a novel type of non-protein coding transcripts that play an important role in pancreatic carcinogenesis. We herein aimed to meta-analyze the diagnostic and prognostic significance of lncRNA expression profiles in PC. A comprehensive retrieval of eligible studies was performed based on the online databases. Quantitative meta-analyses of the pooled diagnostic parameters and hazard ratios (HRs) were enabled by using standard statistical methods. A total of 16 studies comprising 1386 PC patients were included. The pooled effect sizes exhibited that lncRNA expression profile achieved a combined sensitivity of 0.82 (95% CI: 0.72-0.89), specificity of 0.77 (95% CI: 0.65

SUBMITTER: Lei L 

PROVIDER: S-EPMC5687677 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature