Homeobox protein CDX2 as a prognostic biomarker in solid malignancies: a meta-analysis.

ABSTRACT:

Background

CDX2 is a caudal-homeobox gene and its expression is abnormal in numerous tumour cell types. Nevertheless, its prognostic value for solid tumours requires further investigation. Hence, we conducted a meta-analysis to determine the significance of CDX2 as a prognostic biomarker in solid malignancies systematically.

Materials and methods

We performed a systematic literature search in PUBMED and EMBASE up to May 2017. Retrospective studies comparing the prognostic value of different CDX2 levels in human malignancies were included. Data extractions and methodological assessments were performed separately by two investigators using a standard procedure. The statistical procedures were performed using Review Manager 5.3 and STATA/MP 14.0.

Results

A total of 26 re

SUBMITTER: Yuan J 

PROVIDER: S-EPMC5687678 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature