Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis.

ABSTRACT:

Background

The joint effect of the interaction of alcohol intake, hepatitis B virus (HBV) and hepatitis C virus (HCV) on the risk of cirrhosis is still unexplored because a large sample size is required for this investigation.

Objective

Evaluation of interaction of HBV, HCV and alcohol abuse on the risk of cirrhosis.

Design

We analysed 12,262 consecutive patients with chronic liver disease of various aetiologies referring to 95 Italian liver units in 2001 or 2014. To evaluate the interaction between alcohol abuse, HBV infection, and HCV infection, patients unexposed to either factors were used as reference category. Adjustment for BMI and age was done by multiple logistic regression analysis.

Results

Females were older than males (p<0.01) and less frequently sh

SUBMITTER: Stroffolini T 

PROVIDER: S-EPMC5687716 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature