Quantifying indices of short- and long-range white matter connectivity at each cortical vertex.

ABSTRACT: Several neurodevelopmental diseases are characterized by impairments in cortical morphology along with altered white matter connectivity. However, the relationship between these two measures is not yet clear. In this study, we propose a novel methodology to compute and display metrics of white matter connectivity at each cortical point. After co-registering the extremities of the tractography streamlines with the cortical surface, we computed two measures of connectivity at each cortical vertex: the mean tracts' length, and the proportion of short- and long-range connections. The proposed measures were tested in a clinical sample of 62 patients with 22q11.2 deletion syndrome (22q11DS) and 57 typically developing individuals. Using these novel measures, we achieved a fine-grained visualizat

SUBMITTER: Padula MC 

PROVIDER: S-EPMC5687731 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature