Notch signaling and progenitor/ductular reaction in steatohepatitis.

ABSTRACT:

Background and objective

Persistent hepatic progenitor cells (HPC) activation resulting in ductular reaction (DR) is responsible for pathologic liver repair in cholangiopathies. Also, HPC/DR expansion correlates with fibrosis in several chronic liver diseases, including steatohepatitis. Increasing evidence indicates Notch signaling as a key regulator of HPC/DR response in biliary and more in general liver injuries. Therefore, we aimed to investigate the role of Notch during HPC/DR activation in a mouse model of steatohepatitis.

Methods

Steatohepatitis was generated using methionine-choline deficient (MCD) diet. For hepatocyte lineage tracing, R26R-YFP mice were infected with AAV8-TBG-Cre.

Results

MCD diet promoted a strong HPC/DR response that progressively diffused i

SUBMITTER: Morell CM 

PROVIDER: S-EPMC5687773 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature