Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial.

ABSTRACT:

Background

Worsening heart failure (WHF) symptoms despite initial therapy during admission for acute heart failure (AHF) is associated with worse outcomes. The association between the time of the WHF event and the intensity of WHF therapy with outcomes is unknown.

Methods and results

In the PROTECT trial of 2033 AHF patients, we investigated the association between time of occurrence of WHF and intensity of therapy, with subsequent outcomes. WHF was defined by standardized, physician-determined assessment. Early WHF was defined as occurring on days 2-3 and late on days 4-7. Low intensity included restarting/increasing diuretics or vasodilators and high intensity included initiation of inotropes, vasopressors, inodilators, or mechanical support. Outcomes were death or cardiov

SUBMITTER: Mentz RJ 

PROVIDER: S-EPMC5687792 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature