Comparative genomic analysis of esophageal squamous cell carcinoma between Asian and Caucasian patient populations.

ABSTRACT: Esophageal squamous cell carcinoma is a major histological type of esophageal cancer, with distinct incidence and survival patterns among races. Although previous studies have characterized somatic mutations in this disease, a rigorous comparison between different patient populations has not been conducted. Here we sequence the samples of 316 Chinese patients, combine them with those from The Cancer Genome Atlas, and perform a comparative analysis between Asian and Caucasian patients. We find that mutated CSMD3 is associated with better prognosis in Asian patients. Applying a robust computational strategy that adjusts for both technical and biological confounding factors, we find that TP53, EP300, and NFE2L2 show higher mutational frequencies in Asian patients. Moreover, NFE2L2 mutations c

SUBMITTER: Deng J 

PROVIDER: S-EPMC5688099 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature