Ontology highlight
ABSTRACT:
SUBMITTER: Sahu SK
PROVIDER: S-EPMC5688138 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171115 1
The set of events that convert adherent epithelial cells into migratory cells are collectively known as epithelial-mesenchymal transition (EMT). EMT is involved during development, for example, in triggering neural crest migration, and in pathogenesis such as metastasis. Here we discover FBXO32, an E3 ubiquitin ligase, to be critical for hallmark gene expression and phenotypic changes underlying EMT. Interestingly, FBXO32 directly ubiquitinates CtBP1, which is required for its stability and nucl ...[more]