Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

ABSTRACT: Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and increased numbers of IL-17A⁺GM-CSF⁺ double-producing CD4, CD8, γδ and NK cells. GM-CSF production in CD4 T cells occurs both independently and in combination with classical Th1 and Th17 cytokines. Type 3 innate lymphoid cells producing predominantly GM-CSF are expanded in synovial tissues from patients with spondyloarthritis. GM-CSF⁺CD4⁺ cells, isolated using a triple cytokine capture approach, have a specific transcriptional signature. Both GM-CSF⁺ and IL-17A⁺

SUBMITTER: Al-Mossawi MH 

PROVIDER: S-EPMC5688161 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature