Diagnostic accuracy of tests to detect Hepatitis C antibody: a meta-analysis and review of the literature.

ABSTRACT:

Background

Although direct-acting antivirals can achieve sustained virological response rates greater than 90% in Hepatitis C Virus (HCV) infected persons, at present the majority of HCV-infected individuals remain undiagnosed and therefore untreated. While there are a wide range of HCV serological tests available, there is a lack of formal assessment of their diagnostic performance. We undertook a systematic review and meta-analysis to evaluate he diagnostic accuracy of available rapid diagnostic tests (RDT) and laboratory based EIA assays in detecting antibodies to HCV.

Methods

We used the PRISMA checklist and Cochrane guidance to develop our search protocol. The search strategy was registered in PROSPERO (CRD42015023567). The search focused on hepatitis C, diagnostic test

SUBMITTER: Tang W 

PROVIDER: S-EPMC5688422 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature