SPRINT: ultrafast protein-protein interaction prediction of the entire human interactome.

ABSTRACT:

Background

Proteins perform their functions usually by interacting with other proteins. Predicting which proteins interact is a fundamental problem. Experimental methods are slow, expensive, and have a high rate of error. Many computational methods have been proposed among which sequence-based ones are very promising. However, so far no such method is able to predict effectively the entire human interactome: they require too much time or memory.

Results

We present SPRINT (Scoring PRotein INTeractions), a new sequence-based algorithm and tool for predicting protein-protein interactions. We comprehensively compare SPRINT with state-of-the-art programs on seven most reliable human PPI datasets and show that it is more accurate while running orders of magnitude faster and using

SUBMITTER: Li Y 

PROVIDER: S-EPMC5688644 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature