Anisotropic Muller glial scaffolding supports a multiplex lattice mosaic of photoreceptors in zebrafish retina.

ABSTRACT:

Background

The multiplex, lattice mosaic of cone photoreceptors in the adult fish retina is a compelling example of a highly ordered epithelial cell pattern, with single cell width rows and columns of cones and precisely defined neighbor relationships among different cone types. Cellular mechanisms patterning this multiplex mosaic are not understood. Physical models can provide new insights into fundamental mechanisms of biological patterning. In earlier work, we developed a mathematical model of photoreceptor cell packing in the zebrafish retina, which predicted that anisotropic mechanical tension in the retinal epithelium orients planar polarized adhesive interfaces to align the columns as cone photoreceptors are generated at the retinal margin during post-embryonic growth.

Me

SUBMITTER: Nagashima M 

PROVIDER: S-EPMC5688757 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature