Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models.

ABSTRACT:

Background

The neuroprotective effects of neuroserpin (NSP) have been well documented in both patients and animal models with cerebral ischemia; however, have never been investigated in hemorrhagic stroke. The aim of this study is to verify the neuroprotection of NSP in the non-tPA-induced intracerebral hemorrhage (ICH) mouse model.

Methods

C57BL/6J male mice (n = 198) were involved in this study. ICH models were established with infusion of autologous blood into the brain parenchyma. We then detected NSP expression in ICH brains by morphological methods and western blotting analysis. We measured the brain water content and detected blood-brain barrier (BBB) permeability to verify the neuroprotective effects of NSP.

Results

We found that NSP protein expression was upr

SUBMITTER: Li W 

PROVIDER: S-EPMC5688810 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature