Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model.

ABSTRACT: Degeneration of the intervertebral discs is a progressive cascade of cellular, compositional and structural changes that is frequently associated with low back pain. As the first signs of disc degeneration typically arise in the disc's central nucleus pulposus (NP), augmentation of the NP via hydrogel injection represents a promising strategy to treat early to mid-stage degeneration. The purpose of this study was to establish the translational feasibility of a triple interpenetrating network hydrogel composed of dextran, chitosan, and teleostean (DCT) for augmentation of the degenerative NP in a preclinical goat model. Ex vivo injection of the DCT hydrogel into degenerated goat lumbar motion segments restored range of motion and neutral zone modulus towards physiologic values. To facilitat

SUBMITTER: Gullbrand SE 

PROVIDER: S-EPMC5688915 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature