A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder.

ABSTRACT:

Objective

Depression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD.

Methods

Subjects were 40 youth (mean 12.7 years, range 9-17 years) who had (1) a first-degree relative with lifetime history of BD I or II, (2) DSM-IV-TR diagnoses of BD not otherwise specified, major depressive disorder or cyclothymic disorder, and (3) active symptoms of depression, mania, or hypomania. Participant

SUBMITTER: Schneck CD 

PROVIDER: S-EPMC5689113 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature