^* Glioblastoma Exosomes for Therapeutic Angiogenesis in Peripheral Ischemia.

ABSTRACT: Peripheral ischemia as a result of occlusive vascular disease is a widespread problem in patients older than the age of 65. Angiogenic therapies that can induce microvascular growth have great potential for providing a long-lasting solution for patients with ischemia and would provide an appealing alternative to surgical and percutaneous interventions. However, many angiogenic therapies have seen poor efficacy in clinical trials, suggesting that patients with long-term peripheral ischemia have considerable therapeutic resistance to angiogenic stimuli. Glioblastoma is one of the most angiogenic tumor types, inducing robust vessel growth in the area surrounding the tumor. One major angiogenic mechanism used by the tumor cells to induce blood vessel growth is the production of exosomes and ot

SUBMITTER: Monteforte A 

PROVIDER: S-EPMC5689131 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature