Unraveling the evolution and coevolution of small regulatory RNAs and coding genes in Listeria.

ABSTRACT:

Background

Small regulatory RNAs (sRNAs) are widely found in bacteria and play key roles in many important physiological and adaptation processes. Studying their evolution and screening for events of coevolution with other genomic features is a powerful way to better understand their origin and assess a common functional or adaptive relationship between them. However, evolution and coevolution of sRNAs with coding genes have been sparsely investigated in bacterial pathogens.

Results

We designed a robust and generic phylogenomics approach that detects correlated evolution between sRNAs and protein-coding genes using their observed and inferred patterns of presence-absence in a set of annotated genomes. We applied this approach on 79 complete genomes of the Listeria genus and

SUBMITTER: Cerutti F 

PROVIDER: S-EPMC5689173 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature