Engineering of nanoparticle size via electrohydrodynamic jetting.

ABSTRACT: Engineering the physical properties of particles, especially their size, is an important parameter in the fabrication of successful carrier systems for the delivery of therapeutics. Here, various routes were explored for the fabrication of particles in the nanosize regime. It was demonstrated that the use of a charged species and/or solvent with high dielectric constant can influence the size and distribution of particles, with the charged species having a greater effect on the size of the particles and the solvent a greater effect on the distribution of the particles. In addition to the fabrication of nanoparticles, their fractionation into specific size ranges using centrifugation was also investigated. The in vitro particle uptake and intracellular transport of these nanoparticles was s

SUBMITTER: Rahmani S 

PROVIDER: S-EPMC5689507 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature