Tunable particles alter macrophage uptake based on combinatorial effects of physical properties.

ABSTRACT: The ability to tune phagocytosis of particle-based therapeutics by macrophages can enhance their delivery to macrophages or reduce their phagocytic susceptibility for delivery to non-phagocytic cells. Since phagocytosis is affected by the physical and chemical properties of particles, it is crucial to identify any interplay between physical properties of particles in altering phagocytic interactions. The combinatorial effect of physical properties size, shape and stiffness was investigated on Fc receptor mediated macrophage interactions by fabrication of layer-by-layer tunable particles of constant surface chemistry. Our results highlight how changing particle stiffness affects phagocytic interaction intricately when combined with varying size or shape. Increase in size plays a dominant ro

SUBMITTER: Garapaty A 

PROVIDER: S-EPMC5689517 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature