ARHI is a novel epigenetic silenced tumor suppressor in sporadic pheochromocytoma.

ABSTRACT: Pheochromocytoma (PCC) is related to germline mutations in 12 susceptibility genes. Although comparative genomic hybridization array has revealed some putative tumor suppressor genes on the short arm of chromosome 1 that are likely to be involved in PCC tumorigenesis, the molecules involved, except for those encoded by known susceptibility genes, have not been found in the generation of sporadic tumors. In the present work, we first identified that the unmethylated allele of Aplasia Ras homolog member I (ARHI) was deleted in most PCC tumors which retained a hypermethylated copy, while its mRNA level was significantly correlated with the unmethylated copy. De-methylation experiments confirmed that expression of ARHI was also regulated by the methylation level of the remaining allele.

SUBMITTER: Wang D 

PROVIDER: S-EPMC5689688 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature