Association between CYP2E1 genetic polymorphisms and urinary cancer risk: a meta-analysis.

ABSTRACT:

Objective

Studies investigating the contribution of Cytochrome P4502E1 (CYP2E1) polymorphisms to the etiology of urinary cancer draw inconsistent conclusions. Thus, we performed a meta-analysis to evaluate the association between CYP2E1 Rsa I/Pst I and Dra I polymorphisms and urinary cancer susceptibility.

Materials and methods

Meta-analysis based on the eligible case-control studies that assess the association of CYP2E1 Rsa I/Pst I and Dra I polymorphisms with urinary cancer was conducted. Subgroup analyses based on ethnicity and cancer type were also carried out. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the associations between the two polymorphisms. Funnel plot and Begg's test were used for publication bias diagnos

SUBMITTER: Fang Z 

PROVIDER: S-EPMC5689730 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature