S100A14 rs11548103 G>A polymorphism is associated with a decreased risk of esophageal cancer in a Chinese population.

ABSTRACT:

Objective

In China in 2009, esophageal cancer was the fifth most commonly diagnosed malignancy and the fourth leading cause of malignancy-related death. Accumulating evidence indicates that genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis.

Materials and methods

In total, we recruited 629 ESCC patients and 686 controls. Genetic variations in the S100A14, MLH1, SMAD7 and CCL22/MDC genes were measured using the ligation detection reaction method.

Results

When the S100A14 rs11548103 GG genotype was considered as the reference group, the GA genotype associated with decreased risk of ESCC (GA vs. GG: adjusted OR = 0.73, 95% CI = 0.57-0.93, p = 0.009). In the dominant model, GA/AA variants were associated with a

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC5689736 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature