Effects of Transendocardial CD34⁺ Cell Transplantation on Diastolic Parameters in Patients with Nonischemic Dilated Cardiomyopathy.

ABSTRACT: We sought to evaluate the physiological background and the effects of CD34⁺ cell transplantation on diastolic parameters in nonischemic dilated cardiomyopathy patients (DCM). We enrolled 38 DCM patients with NYHA class III and LVEF < 40% who underwent transendocardial CD34⁺ cell transplantation. Peripheral blood CD34⁺ cells were mobilized by G-CSF, collected via apheresis, and injected transendocardially in the areas of myocardial hibernation. Patients were followed for 1 year. At baseline, estimated filling pressures were significantly elevated (E/e' ≥ 15) in 18 patients (Group A), and moderately elevated (E/e '< 15) in 20 patients (Group B). The groups did not differ in age (54 ± 9 years vs. 52 ± 10 years; p = .62), gender (male: 85% vs. 78%; p = .57), or

SUBMITTER: Bervar M 

PROVIDER: S-EPMC5689759 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature