On the species of origin: diagnosing the source of symbiotic transcripts.

ABSTRACT:

Background

Most organisms have developed ways to recognize and interact with other species. Symbiotic interactions range from pathogenic to mutualistic. Some molecular mechanisms of interspecific interaction are well understood, but many remain to be discovered. Expressed sequence tags (ESTs) from cultures of interacting symbionts can help identify transcripts that regulate symbiosis, but present a unique challenge for functional analysis. Given a sequence expressed in an interaction between two symbionts, the challenge is to determine from which organism the transcript originated. For high-throughput sequencing from interaction cultures, a reliable computational approach is needed. Previous investigations into GC nucleotide content and comparative similarity searching provide prov

SUBMITTER: Hraber PT 

PROVIDER: S-EPMC56898 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature