Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.

ABSTRACT: Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis infection to pulmonary tuberculosis disease in humans remains limited. To define such mechanisms, we followed M. tuberculosis-infected adolescents longitudinally. Blood samples from forty-four adolescents who ultimately developed tuberculosis disease (“progressors”) were compared with those from 106 matched controls, who remained healthy during two years of follow up. We performed longitudinal whole blood transcriptomic analyses by RNA sequencing and plasma proteome analyses using multiplexed slow off-rate modified DNA aptamers. Tuberculosis progression was associated with sequential modulation of immunological processes. Type I/II interferon signalling and complement cascade were elevated 18 months befo

SUBMITTER: Scriba TJ 

PROVIDER: S-EPMC5689825 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature