A complete 4DCT-ventilation functional avoidance virtual trial: Developing strategies for prospective clinical trials.

ABSTRACT:

Introduction

4DCT-ventilation is an exciting new imaging modality that uses 4DCT data to calculate lung-function maps. Because 4DCTs are acquired as standard of care for lung cancer patients undergoing radiotherapy, 4DCT-ventiltation provides functional information at no extra dosimetric or monetary cost to the patient. The development of clinical trials is underway to use 4DCT-ventilation imaging to spare functional lung in patients undergoing radiotherapy. The purpose of this work was to perform a virtual trial using retrospective data to develop the practical aspects of a 4DCT-ventilation functional avoidance clinical trial.

Methods

The study included 96 stage III lung cancer patients. A 4DCT-ventilation map was calculated using the patient's 4DCT-imaging, deformable regi

SUBMITTER: Waxweiler T 

PROVIDER: S-EPMC5689844 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature