Online dosimetric evaluation of larynx SBRT: A pilot study to assess the necessity of adaptive replanning.

ABSTRACT:

Purpose

We have initiated a multi-institutional phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for Stage III-IVa laryngeal cancer. We conducted this pilot dosimetric study to confirm potential utility of online adaptive replanning to preserve treatment quality.

Methods

We evaluated ten cases: five patients enrolled onto the current trial and five patients enrolled onto a separate phase I SBRT trial for early-stage glottic larynx cancer. Baseline SBRT treatment plans were generated per protocol. Daily cone-beam CT (CBCT) or diagnostic CT images were acquired prior to each treatment fraction. Simulation CT images and target volumes were deformably registered to daily volumetric images, the original SBRT plan was copied to the deformed images and contours, de

SUBMITTER: Mao W 

PROVIDER: S-EPMC5689891 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature