Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.

ABSTRACT: Accurate analysis of placental and fetal oxygenation is critical during pregnancy. Photoacoustic imaging (PAI) combines laser technology with ultrasound in real time. We tested the sensitivity and accuracy of PAI for analysis of placental and fetal oxygen saturation (sO₂) in mice. The placental labyrinth (L) had a higher sO₂ than the junctional zone plus decidua region (JZ+D) in C57Bl/6 mice. Changing maternal O₂ from 100 to 20% in C57Bl/6 mice lowered sO₂ in these regions. C57Bl/6 mice were treated with the NO synthase inhibitor L-N^G-nitroarginine methyl ester (L-NAME) from gestational day (GD) 11 to GD18 to induce hypertension. L-NAME decreased sO₂ in L and JZ+D at GD14 and GD18 in association with fetal growth restriction

SUBMITTER: Yamaleyeva LM 

PROVIDER: S-EPMC5690392 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature