Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.

ABSTRACT:

Objective

The role of bradykinin (BK) receptors in activating and sensitizing peripheral nociceptors is well known. Recently, we showed that spinal dynorphin was pronociceptive through direct or indirect BK receptor activation. Here, we explored the potential role of BK receptors in pain associated with persistent pancreatitis in rats.

Methods

Experimental pancreatitis and abdominal hypersensitivity were induced by intravenous administrations of dibutyltin dichloride (DBTC). [des-Arg-Leu]BK (B1 antagonist) and HOE 140 (B2 antagonist) were given by intraperitoneal or intrathecal injection. Dynorphin antiserum was given intrathecally. Reverse transcription-polymerase chain reaction was used to detect spinal mRNA for BK receptors.

Results

Dibutyltin dichloride-induced pa

SUBMITTER: Chen Q 

PROVIDER: S-EPMC5690478 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature