³¹ P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo.

ABSTRACT: The purpose of this work was to develop a ³¹ P spectroscopic magnetic resonance fingerprinting (MRF) method for fast quantification of the chemical exchange rate between phosphocreatine (PCr) and adenosine triphosphate (ATP) via creatine kinase (CK). A ³¹ P MRF sequence (CK-MRF) was developed to quantify the forward rate constant of ATP synthesis via CK ( kfCK), the T₁ relaxation time of PCr ( T1PCr), and the PCr-to-ATP concentration ratio ( MRPCr). The CK-MRF sequence used a balanced steady-state free precession (bSSFP)-type excitation with ramped flip angles and a unique saturation scheme sensitive to the exchange between PCr and γATP. Parameter estimation was accomplished by matching the acquired signals to a dictionary generated using the Bloch-McConnel

SUBMITTER: Wang CY 

PROVIDER: S-EPMC5690599 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature