Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression.

ABSTRACT: Purpose: VEGF-targeted therapies have modest efficacy in cancer patients, but acquired resistance is common. The mechanisms underlying such resistance are poorly understood.Experimental Design: To evaluate the potential role of immune cells in the development of resistance to VEGF blockade, we first established a preclinical model of adaptive resistance to anti-VEGF therapy. Additional in vitro and in vivo studies were carried out to characterize the role of macrophages in such resistance.Results: Using murine cancer models of adaptive resistance to anti-VEGF antibody (AVA), we found a previously unrecognized role of macrophages in such resistance. Macrophages were actively recruited to the tumor microenvironment and were responsible for the emergence of

SUBMITTER: Dalton HJ 

PROVIDER: S-EPMC5690831 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature