Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages.

ABSTRACT: Design principles of biological networks have been studied extensively in the context of protein-protein interaction networks, metabolic networks, and regulatory (transcriptional) networks. Here we consider regulation networks that occur on larger scales, namely the cell-to-cell signaling networks that connect groups of cells in multicellular organisms. These are the feedback loops that orchestrate the complex dynamics of cell fate decisions and are necessary for the maintenance of homeostasis in stem cell lineages. We focus on "minimal" networks that are those that have the smallest possible numbers of controls. For such minimal networks, the number of controls must be equal to the number of compartments, and the reducibility/irreducibility of the network (whether or not it can be split i

SUBMITTER: Komarova NL 

PROVIDER: S-EPMC5690898 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature