Frailty is an independent predictor of incident dementia: Evidence from the English Longitudinal Study of Ageing.

ABSTRACT: The aim of this study was to determine whether frailty in older adults is associated with the risk of subsequent dementia. A total of 8,722 older adults from the English Longitudinal Study of Ageing were followed-up every two years until they reported a diagnosis of dementia, died, or were right censored. Frailty was defined using a frailty index comprised of 47 health deficits. To test if cognitive function influences the relationship between frailty and incident dementia, the analyses were repeated according to lower or upper three quartiles of baseline cognitive function. Competing risks regression and Cox proportional hazard models were used to evaluate whether the degree of baseline frailty was associated with incident dementia. Compared with non-frail participants, pre-frail (HR: 1.5

SUBMITTER: Rogers NT 

PROVIDER: S-EPMC5691042 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature