Protein and fat meal content increase insulin requirement in children with type 1 diabetes - Role of duration of diabetes.

ABSTRACT:

Background and objective

Hyperglycaemia remains a challenge in type 1 diabetes since current regimes used to determine meal insulin requirements prove to be ineffective. This is particularly problematic for meals containing high amounts of protein and fat. We aimed to determine the post-prandial glycaemic response and total insulin need for mixed meals, using sensor-augmented insulin pumps in children with type 1 diabetes.

Methods

Twenty-two children with type 1 diabetes, aged 4-17 years on insulin pump therapy completed this home-based, cross-over, randomised controlled trial. Two meals with identical carbohydrate content - one with low fat and protein (LFLP) and one with high fat and protein (HFHP) contents - were consumed using normal insulin boluses. Blood glucose monito

SUBMITTER: van der Hoogt M 

PROVIDER: S-EPMC5691219 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature