Gibberellin-regulated protein in Japanese apricot is an allergen cross-reactive to Pru p 7.

ABSTRACT:

Background

Gibberellin-regulated protein (GRP, also known as peamaclein) was recently identified as a new marker allergen related to systemic reactions in peach allergy; however, its role in other fruit allergies is unknown.

Objective

To investigate the allergenicity of Japanese apricot (JA) GRP and clarify the clinical characteristics of JA allergy patients with GRP sensitization.

Methods

Seven patients (two males, five females, mean age 28.0 years) diagnosed with JA allergy based on relevant clinical history, positive skin test and/or challenge test were enrolled. JA GRP with a molecular weight of 6896.5 Da was purified by ion-exchange column chromatography. We performed enzyme-linked immunosorbent assay (ELISA), IgE-immunoblotting, basophil activating tests (BATs),

SUBMITTER: Inomata N 

PROVIDER: S-EPMC5691307 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature