Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg?

ABSTRACT:

Introduction

Although intravenous immunoglobulin (IVIg) is commonly used in the clinic to treat various autoimmune and severe inflammatory diseases, the mode of action is not fully elucidated. This work investigates two proposed mechanisms: (1) the potential role of regulatory T-cell epitopes (Tregitopes) from the constant domain of IgG in the immunosuppressive function of IVIg; and (2) a potential impact of IVIg on the ability of antigen presenting cells (APCs) to present peptides.

Methods and results

Investigation of the HLA class II peptide repertoire from IVIg-loaded dendritic cells (DCs) via MHC-associated peptide proteomics (MAPPs) revealed that numerous IgG-derived peptides were strongly presented along the antibody sequence. Surprisingly, Tregitopes 167 and 289 did n

SUBMITTER: Sorde L 

PROVIDER: S-EPMC5691310 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature