Depletion of FoxP3⁺ Tregs improves control of larval Echinococcus multilocularis infection by promoting co-stimulation and Th1/17 immunity.

ABSTRACT:

Introduction

The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. Previous studies had shown that regulatory T cells (Tregs) become gradually up-regulated in the course of both chronic human and murine AE. Thus we now tackled the role of FoxP3⁺ Tregs and FoxP3⁺ -Treg-regulated immune response in contributing to the control of this helminthic infection.

Methods

The infection outcome in E. multilocularis-infected DEREG mice was measured upon determining parasite load (wet weight of parasitic metacestode tissue). Flow cytometry and qRT-PCR were used to assess Treg, Th17-, Th1-, Th2-type immune respon

SUBMITTER: Wang J 

PROVIDER: S-EPMC5691311 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature